Give Patients with ALS a Chance Help Slow the Loss of Physical Function

RADICAVA® (edaravone) is the only FDA-approved treatment option for amyotrophic lateral sclerosis (ALS) that was shown to slow the decline of physical function in a pivotal clinical trial.1,a

1000+ healthcare providers have prescribed RADICAVA® in the US as of January 21, 2019
4000+ patients treated with RADICAVA® in the US as of June 2019
67% of patients stay on RADICAVA® for at least 6 months Based on data collected from August 2017-January 2019.2

aAs measured by total score on the ALS Functional Rating Scale–Revised (ALSFRS-R) in a 24-week study of 137 participants.1 Individual results may vary.

References: 1. RADICAVA Prescribing Information. Jersey City, NJ: Mitsubishi Tanabe Pharma America, Inc.; 2018. 2. Data on file. Mitsubishi Tanabe Pharma America, Inc.

Important Safety Information

Hypersensitivity Reactions

Radicava® (edaravone) is contraindicated in patients with a history of hypersensitivity to edaravone or any of the inactive ingredients in Radicava®. Hypersensitivity reactions (redness, wheals, and erythema multiforme) and cases of anaphylaxis (urticaria, decreased blood pressure, and dyspnea) have been reported. Patients should be monitored carefully for hypersensitivity reactions, and if they occur, discontinue Radicava®, treat per standard of care, and monitor until the condition resolves.

Sulfite Allergic Reactions

Radicava® contains sodium bisulfite, and may cause allergic type reactions, including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown, but occurs more frequently in asthmatic people.

Most Common Adverse Reactions

Most common adverse reactions (at least 10% and greater than placebo) are contusion, gait disturbance, and headache.

Pregnancy

Based on animal data, Radicava® may cause fetal harm.

Geriatric Use

No overall differences in safety or effectiveness were observed between patients 65 years of age and older and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

To report suspected adverse reactions or product complaints, contact Mitsubishi Tanabe Pharma America, Inc., at 1-888-292-0058. You may also report suspected adverse reactions to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Indication

Radicava® is indicated for the treatment of amyotrophic lateral sclerosis (ALS).

Please see full Prescribing Information.

For more information about RADICAVA®, call 1-888-292-0058.